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What's the alternative. The alternative at that time was dessicated thyroid extract. Desiccated thyroid extract had two problems. First there is swing of three levels that may or may depending on how much you take may or may not be a problem. But the major criticism physicians had was for the inconsistency of the content of active thyroid hormone in those preparations.

So I wasn't clinically active in the 70s or 60s but I heard, I here and there's some reports in the literature that sometimes physicians will prescribe patients of a certain brand of desiccated thyroid extract and that will not work at all. I figured I guess pharmaceutical companies had issues or problems with storage or shelf life of those products that I but I also think that this is sort of was probably more important 56 years ago than it is today.

We have heard very little about inconsistency of the doses. And frankly levothyroxine also has certain inconsistencies depending on the brand, depending on the generic. So that I think this has is a problem of the past but we need verification of that.

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What is the alternative to using monotherapy with levothyroxine? And what role has dessicated thyroid extract (DTE) played historically in treating hypothyroidism, and what have we learned from this experience?

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What is the alternative to using monotherapy with levothyroxine? And what role has dessicated thyroid extract (DTE) played historically in treating hypothyroidism, and what have we learned from this experience?

Created by

CMEducation Resources IQ&A Thyroid Hormone Replacement Medical Intelligence Zone

Presenter

Antonio Bianco, MD, PhD

Antonio Bianco, MD, PhD

Professor of Medicine Department of Medicine Division of Endocrinology University of Chicago Chicago, Illinois

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